Kirane Receives 2024 SCI Innovation Award
August 19, 2024
Dr. Amanda Kirane’s proposal, “Functional Oncology Mapping (FuncOMap) to deliver cutting-edge biomarkers for precision immunotherapy application,” was selected for funding as one of the Stanford Cancer Institute’s October 2024 SCI Innovation Awards.
“While groundbreaking advances have been made in melanoma treatment, a significant number of patients still do not respond to first-line therapy or risk severe side effects from treatment,” said Kirane. ”The lack of clinically predictive biomarkers to facilitate therapeutic selection is a frustrating challenge that we have aimed to explore in a way that diverges from conventional protein or gene analyses.”
Kirane has been collaborating with Professor Banafshé Larijani, Director of the Centre for Therapeutic Innovation at the University of Bath and creator of FuncOmap. FuncOmap measures functional immune checkpoint interactions using time-resolved FRET technology. Kirane plans to marry Larijani's novel quantitative imaging assay with advanced multi-plex spatial biology. Thanks to an Equipment Seed Grant earlier this year, Kirane was able to purchase a COMET to facilitate her research.
“By unveiling the intricate molecular signaling dynamics of divergent cellular neighborhoods contributing to therapy responses, we expect this first-in-kind innovative approach to redefine precision immunotherapeutic application,” said Kirane. “This type of technical and computational approach to understanding cellular signaling in complex, whole-tissue multicellular environments will have biologic implications beyond melanoma with a potential future role in many cancers, inflammatory diseases, and immune related phenomena.”
Kirane is an assistant professor in the Division of General Surgery’s surgical oncology section.
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